Health Solution Lab Kits
Resolving Symptoms of Disease through Functional Medicine Technology
Hormone Profiles
Adrenal Stress Plus - Saliva
The Adrenal Stress Plus Profile is a measure of an individual's response to stress. It is also an important tool for pointing to adrenal imbalances that may be impacting a patient's health. The Adrenal Stress Profiles from Metametrix use a non-invasive salivary procedure to monitor the activity of the adrenal cortex and its ability to react to stress. The procedure monitors the circadian variation of cortisol and DHEA-S levels. An increased cortisol level, a decreased DHEA-S level, or a decrease in the DHEA-S/cortisol ratio is an indication of a chronically stressful physical or mental condition.
Estronex Profile - Urine
The Estronex Profile measures six important estrogen metabolites and their ratios to help women, and even men, assess whether he or she is at risk of developing estrogen sensitive cancers such as; breast, uterus, ovaries, cervix, prostate, testes, colon and bones.
Gliadin Sensitivity - Saliva
The Gliadin Sensitivity Profile uses a non-invasive salivary procedure to measure the body’s response to gluten. Secretory IgA protects the gut from pathogenic material. During a high stress situation, levels of secretory IgA decrease. Thus, chronic cortisol elevation may be associated with high antigliadin antibodies due to intestinal hyperpermeability (leaky-gut). Gliadin is a protein component found in wheat.
Toxic Effects Profiles
Phthalates and Parabens Profile - Urine
The Phthalates & Parabens Profile helps assess levels of phthalates and parabens in the body, which can help identify if exposures correlate with health
issues. Phthalates and parabens are known as xenoestrogens, which bind to estrogen receptors and disrupt the endocrine system. Knowing a patient’s body burden of phthalates and parabens can assist in creating treatment plans to help achieve patient wellness.
Organosphates Profile - Urine
Organophosphates can be hazardous to the neurological development of children and babies in the womb, producing lower IQs.(1) Other health effects include chronic fatigue, asthma, wheeze, immune system disorders, impaired memory, disorientation, depression, irritability, flu-like symptoms, and may increase risk of cancer and Alzheimer’s disease. Most exposure to organophosphates occurs from ingestion through the food supply. Direct dermal exposure can also occur for people that work directly with these chemicals.
Bisphenol A Profile - Urine
Endocrine disruptors weakly bind to estrogen receptors which can affect the endocrine, nervous, and immune systems as well as block thyroid hormone action. Exposure to chemicals that are xenoestrogens disrupt the proper function of the body’s endocrine system. Children and babies in the womb are most susceptible to hormonal and neurological development issues from exposure.
Porphyrins Profile - Urine
The Porphyrins Profile can help identify the severity of heavy metal toxicity or organic chemical exposure in patients. Chemical exposure and a heavy toxic burden can have physiological effects resulting in impaired metabolism and cellular function.
Organix Profiles
Since 1992, Metametrix has offered the Organix Profile, a complete quantitative organic acids test. The Organix provides a view into the body's cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic blocks or problems with detoxification, gut dysbiosis, or oxidative stress that can be treated nutritionally allows for individual tailoring of interventions. Targeted treatment can help maximize patient responses and lead to improved patient outcomes.
Organix Comprehensive - Urine
The Organix Comprehensive measures organic acid levels to reveal the nutritional and metabolic basis of patient symptoms, including anxiety, mood changes, and immune responses This test contains one of the most extensive analyte lists in the industry including markers such as Quinolinate, D-Arabinitol, and 8-Hydroxy-2'deoxyguanosine.
Organix Basic - Urine
The Organix Profile provides a view into the body's cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions to help maximize patient responses and lead to improved patient outcomes.
Organix Dysbiosis - Urine
The Russian scientist Elie Metchnikoff (1845 - 1916) popularized the idea of "Dys-symbiosis" or "Dysbiosis," describing an imbalance in the microecology of
the digestive tract. When the microbial balance of the gut is disturbed, opportunistic, or "bad", bacteria can overgrow and mitigate the effects of the "good", predominant bacteria needed for a healthy gut.
DNA/Oxidative Stress Marker - Urine
The interaction of free radicals (ROS) with DNA and RNA produces oxidation products which attach to these pair of moliculesof these base rings. DNA repair enzymes must remove the damaged bases in order to maintain viability. This test is an accurate measure of the rate of polynucleotide oxidative damage. Elevated 8OHdG is a sign that antioxidant nutrient intake may need to be increased. Toxicants and lifestyle stress factors may contribute to increased oxidative challenge.
Integrated Profiles
The TRIAD Bloodspot Profile
The TRIAD Bloodspot Profile allows simultaneous assessment of food sensitivities and intestinal hyperpermeability; urinary microbial metabolites, detoxification indicators, functional vitamin and mineral sufficiency markers, and neural function markers; and essential amino acid status. The TRIAD Profile provides the clinician with a powerful array of clinical tools to design appropriate therapeutic interventions for the patient.
Bloodspot IgG4 Food Antibody Profile
The Bloodspot IgG4 Food Antibody Profile measures levels of IgG4 antibodies specific to 30 commonly offending foods clearly identifying foods causing patient reactions. Testing aids the clinician in the specific dietary change that is needed, helping to achieve positive outcomes sooner, even when combined with elimination or provocation testing.
Element Profile
Nutrition and Toxic Elements - Hair
Hair is unique in its ability to concentrate divalent cations because of the high amount of sulfur amino acids that act as strong binding sites. Toxic heavy metals and essential trace elements are found in hair in levels many times higher than those found in any other tissue. This characteristic makes hair testing a sensitive way to detect body status of many trace elements.
Nutrition and Toxic Elements - 6-8 hour or 24 hour Urine
In the Metametrix Nutrient & Toxic Elements Profile, the total output of urine over 6-8 hours or 24 hours is collected and the daily output of elements is determined. The test may be used with or without administration of chelating agents to assess the rate of excretion of the elements reported.
Toxic Metals 6-8 hour or 24 hour Urine
The total output of urine over 6-8 or 24 hours is collected and the daily output of elements is determined. The test may be used with or without administration of chelating agents to assess the rate of excretion of the elements reported.
GI Effects Stool Profiles
The GI Effects Profile uses DNA analysis to identify microbiota including anaerobes, a previously immeasurable area of the gut environment. DNA
assessment is specific and accurate, avoids the pitfalls of sample transport, reports results as specific numbers, and is more sensitive than classic laboratory methods.
Gastrointesstinal Function Profile - Stool
Gastrointestinal function is important for general health. The intestinal tract contains significant amounts of bacteria; some beneficial, some neutral, and
some harmful. Balancing beneficial microbial flora in the gut is key to proper digestion, efficient nutrient usage, and ridding the body of waste and
pathogens. Poor digestion and malabsorption can lead to immune dysfunction, nutritional insufficiencies, mental/emotional disorders, and autoimmune diseases.
Microbial Ecology Profile - Stool
Microbial Ecology Profile identifies predominate, opportunistic, and pathogenic bacteria using DNA analysis. Other analytes included are yeast/fungi, parasites, adiposity index, and microbial and fungi sensitivities. This profile helps monitor the intestinal microflora of the gut that are central
to colonization resistance, which prevents colonization of the gut by pathogens.
Chemistries Profile - Stool
This profile helps identify inflammatory and immune response, which is important since the gut makes up almost 80% of the body’s immune system. Short chain fatty acids (SCFAs), inflammation, immunology, red blood cells, as well as digestion and absorption abilities are the focus of this GI profile.
Mycology Profile - Stool
The Microbial Profile uses DNA analysis to identify microbiota including anaerobes, a previously immeasurable area of the gut environment. DNA
assessment is specific and accurate, avoids the pitfalls of sample transport, reports results as specific numbers, and is more sensitive than classic
laboratory methods.
Parasitology Profile - Stool
Parasitology Profile helps identify if parasitic protozoans or worms are present in the gut, and is a cost-effective follow-up test to monitor targeted treatment. It is estimated that at least one-third of the world’s population is infected with intestinal parasites, making infections with these organisms one
of the most common infections of humans.
Amino Acids Profiles
Amino acids, known as the "building blocks" of proteins, are found in every tissue of the body. They play a major role in nearly every chemical process that
affects both physical and mental function including the formation of ligaments, tendons, bones, as well as antibodies and regulation of enzymes and blood
transport proteins. Twenty different amino acids are used to synthesize proteins
Amino Acids Profile - 11 or 20 Bloodspot
This profile is available testing 11 or 20 analytes. The Bloodspot Amino Acid Profile can illuminate problems in amino acid absorption by determining essential amino acid imbalances from a simple finger stick.
Fatty Acid Profile
Fatty Acid Profile - Bloodspot
Fatty acid testing can provide a great deal of information allowing for individualized interventions. Varying patterns can help to identify not only
essential fatty acid deficiency or excess, but also signs of insulin resistance, hypertriglyceridemia, proinflammation, or omega-3 dominance.
Health Risk Profiles
Bone Resorption (Deoxypyridinoline) - Urine
Bone is a very active tissue, undergoing constant "remodeling," a process of both formation and resorption. Net loss of bone mass occurs when the resorption rate exceeds the rate of formation of new bone. The rate of bone loss is highly variable from one individual to another. Since the bone formation process is difficult to assess, it is important to identify both men and women with rapid bone resorption. These individuals are at greatest risk for osteoporosis and will benefit most from therapeutic intervention. The Bone Resorption Assay measures the deoxypyridinoline fragment of Type I collagen breakdown from a single urine specimen. This is the fragment that contains the cross-linking point and has been demonstrated to be more specific to bone resorption than breakdown fragments measured in some earlier assays.
Neopterin / Biopterin - Urine
Neopterin and biopterin are by-products of the redox reactions involving tetrahydrobiopterin (BH4). BH4 functions as a cofactor for the enzymes responsible for the production of monoamine neurotransmitters (ephinepherine, norepinephrine, DOPA, serotonin), and as a cofactor in nitric oxide production. Low biopterin levels may reflect insufficient BH4 status. Restricted BH4 cofactor availability has been suggested as an etiologic factor in:
intestine pathology that so often requires treatment in children with Autism Spectrum Disorders.
Adrenal Stress Plus - Saliva
The Adrenal Stress Plus Profile is a measure of an individual's response to stress. It is also an important tool for pointing to adrenal imbalances that may be impacting a patient's health. The Adrenal Stress Profiles from Metametrix use a non-invasive salivary procedure to monitor the activity of the adrenal cortex and its ability to react to stress. The procedure monitors the circadian variation of cortisol and DHEA-S levels. An increased cortisol level, a decreased DHEA-S level, or a decrease in the DHEA-S/cortisol ratio is an indication of a chronically stressful physical or mental condition.
Estronex Profile - Urine
The Estronex Profile measures six important estrogen metabolites and their ratios to help women, and even men, assess whether he or she is at risk of developing estrogen sensitive cancers such as; breast, uterus, ovaries, cervix, prostate, testes, colon and bones.
Gliadin Sensitivity - Saliva
The Gliadin Sensitivity Profile uses a non-invasive salivary procedure to measure the body’s response to gluten. Secretory IgA protects the gut from pathogenic material. During a high stress situation, levels of secretory IgA decrease. Thus, chronic cortisol elevation may be associated with high antigliadin antibodies due to intestinal hyperpermeability (leaky-gut). Gliadin is a protein component found in wheat.
Toxic Effects Profiles
Phthalates and Parabens Profile - Urine
The Phthalates & Parabens Profile helps assess levels of phthalates and parabens in the body, which can help identify if exposures correlate with health
issues. Phthalates and parabens are known as xenoestrogens, which bind to estrogen receptors and disrupt the endocrine system. Knowing a patient’s body burden of phthalates and parabens can assist in creating treatment plans to help achieve patient wellness.
Organosphates Profile - Urine
Organophosphates can be hazardous to the neurological development of children and babies in the womb, producing lower IQs.(1) Other health effects include chronic fatigue, asthma, wheeze, immune system disorders, impaired memory, disorientation, depression, irritability, flu-like symptoms, and may increase risk of cancer and Alzheimer’s disease. Most exposure to organophosphates occurs from ingestion through the food supply. Direct dermal exposure can also occur for people that work directly with these chemicals.
Bisphenol A Profile - Urine
Endocrine disruptors weakly bind to estrogen receptors which can affect the endocrine, nervous, and immune systems as well as block thyroid hormone action. Exposure to chemicals that are xenoestrogens disrupt the proper function of the body’s endocrine system. Children and babies in the womb are most susceptible to hormonal and neurological development issues from exposure.
Porphyrins Profile - Urine
The Porphyrins Profile can help identify the severity of heavy metal toxicity or organic chemical exposure in patients. Chemical exposure and a heavy toxic burden can have physiological effects resulting in impaired metabolism and cellular function.
Organix Profiles
Since 1992, Metametrix has offered the Organix Profile, a complete quantitative organic acids test. The Organix provides a view into the body's cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic blocks or problems with detoxification, gut dysbiosis, or oxidative stress that can be treated nutritionally allows for individual tailoring of interventions. Targeted treatment can help maximize patient responses and lead to improved patient outcomes.
Organix Comprehensive - Urine
The Organix Comprehensive measures organic acid levels to reveal the nutritional and metabolic basis of patient symptoms, including anxiety, mood changes, and immune responses This test contains one of the most extensive analyte lists in the industry including markers such as Quinolinate, D-Arabinitol, and 8-Hydroxy-2'deoxyguanosine.
Organix Basic - Urine
The Organix Profile provides a view into the body's cellular metabolic processes and the efficiency of metabolic function. Identifying metabolic blocks that can be treated nutritionally allows individual tailoring of interventions to help maximize patient responses and lead to improved patient outcomes.
Organix Dysbiosis - Urine
The Russian scientist Elie Metchnikoff (1845 - 1916) popularized the idea of "Dys-symbiosis" or "Dysbiosis," describing an imbalance in the microecology of
the digestive tract. When the microbial balance of the gut is disturbed, opportunistic, or "bad", bacteria can overgrow and mitigate the effects of the "good", predominant bacteria needed for a healthy gut.
DNA/Oxidative Stress Marker - Urine
The interaction of free radicals (ROS) with DNA and RNA produces oxidation products which attach to these pair of moliculesof these base rings. DNA repair enzymes must remove the damaged bases in order to maintain viability. This test is an accurate measure of the rate of polynucleotide oxidative damage. Elevated 8OHdG is a sign that antioxidant nutrient intake may need to be increased. Toxicants and lifestyle stress factors may contribute to increased oxidative challenge.
Integrated Profiles
The TRIAD Bloodspot Profile
The TRIAD Bloodspot Profile allows simultaneous assessment of food sensitivities and intestinal hyperpermeability; urinary microbial metabolites, detoxification indicators, functional vitamin and mineral sufficiency markers, and neural function markers; and essential amino acid status. The TRIAD Profile provides the clinician with a powerful array of clinical tools to design appropriate therapeutic interventions for the patient.
Bloodspot IgG4 Food Antibody Profile
The Bloodspot IgG4 Food Antibody Profile measures levels of IgG4 antibodies specific to 30 commonly offending foods clearly identifying foods causing patient reactions. Testing aids the clinician in the specific dietary change that is needed, helping to achieve positive outcomes sooner, even when combined with elimination or provocation testing.
Element Profile
Nutrition and Toxic Elements - Hair
Hair is unique in its ability to concentrate divalent cations because of the high amount of sulfur amino acids that act as strong binding sites. Toxic heavy metals and essential trace elements are found in hair in levels many times higher than those found in any other tissue. This characteristic makes hair testing a sensitive way to detect body status of many trace elements.
Nutrition and Toxic Elements - 6-8 hour or 24 hour Urine
In the Metametrix Nutrient & Toxic Elements Profile, the total output of urine over 6-8 hours or 24 hours is collected and the daily output of elements is determined. The test may be used with or without administration of chelating agents to assess the rate of excretion of the elements reported.
Toxic Metals 6-8 hour or 24 hour Urine
The total output of urine over 6-8 or 24 hours is collected and the daily output of elements is determined. The test may be used with or without administration of chelating agents to assess the rate of excretion of the elements reported.
GI Effects Stool Profiles
The GI Effects Profile uses DNA analysis to identify microbiota including anaerobes, a previously immeasurable area of the gut environment. DNA
assessment is specific and accurate, avoids the pitfalls of sample transport, reports results as specific numbers, and is more sensitive than classic laboratory methods.
Gastrointesstinal Function Profile - Stool
Gastrointestinal function is important for general health. The intestinal tract contains significant amounts of bacteria; some beneficial, some neutral, and
some harmful. Balancing beneficial microbial flora in the gut is key to proper digestion, efficient nutrient usage, and ridding the body of waste and
pathogens. Poor digestion and malabsorption can lead to immune dysfunction, nutritional insufficiencies, mental/emotional disorders, and autoimmune diseases.
Microbial Ecology Profile - Stool
Microbial Ecology Profile identifies predominate, opportunistic, and pathogenic bacteria using DNA analysis. Other analytes included are yeast/fungi, parasites, adiposity index, and microbial and fungi sensitivities. This profile helps monitor the intestinal microflora of the gut that are central
to colonization resistance, which prevents colonization of the gut by pathogens.
Chemistries Profile - Stool
This profile helps identify inflammatory and immune response, which is important since the gut makes up almost 80% of the body’s immune system. Short chain fatty acids (SCFAs), inflammation, immunology, red blood cells, as well as digestion and absorption abilities are the focus of this GI profile.
Mycology Profile - Stool
The Microbial Profile uses DNA analysis to identify microbiota including anaerobes, a previously immeasurable area of the gut environment. DNA
assessment is specific and accurate, avoids the pitfalls of sample transport, reports results as specific numbers, and is more sensitive than classic
laboratory methods.
Parasitology Profile - Stool
Parasitology Profile helps identify if parasitic protozoans or worms are present in the gut, and is a cost-effective follow-up test to monitor targeted treatment. It is estimated that at least one-third of the world’s population is infected with intestinal parasites, making infections with these organisms one
of the most common infections of humans.
Amino Acids Profiles
Amino acids, known as the "building blocks" of proteins, are found in every tissue of the body. They play a major role in nearly every chemical process that
affects both physical and mental function including the formation of ligaments, tendons, bones, as well as antibodies and regulation of enzymes and blood
transport proteins. Twenty different amino acids are used to synthesize proteins
Amino Acids Profile - 11 or 20 Bloodspot
This profile is available testing 11 or 20 analytes. The Bloodspot Amino Acid Profile can illuminate problems in amino acid absorption by determining essential amino acid imbalances from a simple finger stick.
Fatty Acid Profile
Fatty Acid Profile - Bloodspot
Fatty acid testing can provide a great deal of information allowing for individualized interventions. Varying patterns can help to identify not only
essential fatty acid deficiency or excess, but also signs of insulin resistance, hypertriglyceridemia, proinflammation, or omega-3 dominance.
Health Risk Profiles
Bone Resorption (Deoxypyridinoline) - Urine
Bone is a very active tissue, undergoing constant "remodeling," a process of both formation and resorption. Net loss of bone mass occurs when the resorption rate exceeds the rate of formation of new bone. The rate of bone loss is highly variable from one individual to another. Since the bone formation process is difficult to assess, it is important to identify both men and women with rapid bone resorption. These individuals are at greatest risk for osteoporosis and will benefit most from therapeutic intervention. The Bone Resorption Assay measures the deoxypyridinoline fragment of Type I collagen breakdown from a single urine specimen. This is the fragment that contains the cross-linking point and has been demonstrated to be more specific to bone resorption than breakdown fragments measured in some earlier assays.
Neopterin / Biopterin - Urine
Neopterin and biopterin are by-products of the redox reactions involving tetrahydrobiopterin (BH4). BH4 functions as a cofactor for the enzymes responsible for the production of monoamine neurotransmitters (ephinepherine, norepinephrine, DOPA, serotonin), and as a cofactor in nitric oxide production. Low biopterin levels may reflect insufficient BH4 status. Restricted BH4 cofactor availability has been suggested as an etiologic factor in:
- Neurological Disease - Alzheimer's Disease, Parkinson's Disease, Autism,
- Depression, DOPA-responsive Dystonia
- Insulin Resistance
- Cardiovascular Disease
- Inborn-errors of metabolism: Phenylketonuria, Hyperphenylalaninemia
intestine pathology that so often requires treatment in children with Autism Spectrum Disorders.
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